After starting clomiphene for infertility, ovulation typically occurs within how many days after the last dose?

• A. 1-2 days
• B. 3-4 weeks
• C. 5-10 days
• D. 2-3 months

Answer: (C)

Timing of ovulation after starting clomiphene is about 5 to 10 days after the last dose. Clomiphene works by blocking estrogen receptors in the hypothalamus, tricking the brain into thinking estrogen is low, which increases GnRH release and, in turn, raises FSH and LH to stimulate a follicle to mature and ovulate. The usual regimen is a 5-day course early in the cycle, so the expected ovulation window falls roughly 5–10 days after finishing the medication. Individual variation occurs, but this window is the typical pattern. Ovulation is not expected to occur as soon as 1–2 days after the last dose, nor months later.